Hi @ccakern.alleyne - great question! And thanks for the tag @alexwalkerjones 
It is different for everyone however, in clinic I would expect to see a difference within 10 days and that difference can then improve over the next 3 weeks usually. In fact, when @Kaveh first asked me to estimate when we would start to see a result with valerian, I said 10 days and it turned out that this is exactly what we saw in the tracked results.
So my conversation with patients is usually something like - if you can see any improvement within 10 days (sometimes earlier, sometimes just a glimmer of change) then stick with it for the next 3 weeks to allow the accumulative effect to build up. But if we haven’t seen anything at ALL by 10 days then I would begin to question whether it is the right herb for that person. I’d probably still ask them to stick with it for at least 2-3 weeks but not beyond that if there was no change, and the dose was correct.
Hope that helps! 